E-7386

• Description :

  E-7386 is an orally active CBP/beta-catenin modulator.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  Epigenetic Reader Domain

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/E-7386.html

• Purity :

  98.87

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C(N([C@](CN1CC2=NC(N3CC(N4CCN(CC)CC4)C3)=CC=C2)([H])N5[C@@H](CC6=CC=C(O)C=C6F)C1=O)N(CC=C)CC5=O)NCC7=CC=CC=C7

• Molecular Formula :

  C39H48FN9O4

• Molecular Weight :

  725.85

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Yusaku Hori, et al. E7386, an orally active CBP/beta-catenin modulator, induces T cells infiltration into tumor and enhances antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. Cancer Res 2017;77 (13 Suppl) :Abstract nr 5172.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [1799824-08-0]