E-7386

• Description:

  E-7386 is an orally active CBP/beta-catenin modulator.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319

• Target:

  Epigenetic Reader Domain

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/E-7386.html

• Purity:

  98.87

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(N([C@](CN1CC2=NC(N3CC(N4CCN(CC)CC4)C3)=CC=C2)([H])N5[C@@H](CC6=CC=C(O)C=C6F)C1=O)N(CC=C)CC5=O)NCC7=CC=CC=C7

• Molecular Formula:

  C39H48FN9O4

• Molecular Weight:

  725.85

• Precautions:

  H302, H315, H319

• References & Citations:

  [1]Yusaku Hori, et al. E7386, an orally active CBP/beta-catenin modulator, induces T cells infiltration into tumor and enhances antitumor activity of anti-PD-1 mAb in Wnt1 tumor syngeneic mice model. Cancer Res 2017;77 (13 Suppl) :Abstract nr 5172.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [1799824-08-0]