PRIMA-1

• Description :

  PRIMA-1 (NSC-281668) is a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A.

• Product Name Alternative :

  NSC-281668

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H334

• Target :

  Apoptosis; Autophagy; Ferroptosis; MDM-2/p53

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Autophagy

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/PRIMA-1.html

• Purity :

  98.0

• Solubility :

  DMSO : 50 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

• Smiles :

  O=C1C(CO)(CO)N2CCC1CC2

• Molecular Formula :

  C9H15NO3

• Molecular Weight :

  185.22

• Precautions :

  H302, H334

• References & Citations :

  [1]Cui B, et al. PRIMA-1, a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A. J Clin Endocrinol Metab. 2014 Jun;99 (6) :E962-70.|[2]Zhang Z, et al. Targeting cancer stem cells with p53 modulators. Oncotarget. 2016 Apr 8.|[3]Rao CV, et al. Chemopreventive effects of the p53-modulating agents CP-31398 and Prima-1 in tobacco carcinogen-induced lung tumorigenesis in A/J mice. Neoplasia. 2013 Sep;15 (9) :1018-27.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [5608-24-2]