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Beta-catenin Polyclonal Antibody

CAT: 0498-bs-55228RSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-55228RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
Synonyms
CTNNB; MRD19; armadillo; beta Catenin; CTNNB1
Gene ID
1499
Swiss Prot
P35222
Cellular Locus
Nucleus, Cell membrane, Intracellular
Host
Rabbit
Cross Reactivity
Human, Mouse, Rat
Target
Beta-catenin
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
A synthetic peptide corresponding to a sequence within amino acids 650-750 of human beta-catenin (NP_001895.1) .
Applications
WB, FCM, IHC-P, IP, IHC
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), FCM (1:20-100), IHC-P (1:200-400), IP (1-2ug), IHC ()
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
1499

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