CBX3 Polyclonal Antibody

• Background :

  Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) . Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.

• Synonyms :

  Chromobox protein homolog 3, CBX3, HECH, Heterochromatin protein 1 homolog gamma, HP1 gamma, Modifier 2 protein

• Gene ID :

  11335

• Swiss Prot :

  Q13185

• Host :

  Rabbit

• Cross Reactivity :

  Human

• Target :

  CBX3

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Source :

  Polyclonal antibody raised in rabbit against human CBX3 using two KLH-conjugated synthetic peptides containing a sequence from the N-terminal and the central region of the protein, respectively

• Applications :

  WB, ELISA

• Purification :

  Whole antiserum from rabbit containing 0.05% azide

• Concentration :

  Not Determined

• Dilution :

  WB (1:300-5000), ELISA (1:500-1000)

• Buffer :

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification :

  Unmodified

• Storage Conditions :

  Store at -20°C for 12 months.

• Gene ID URL :

  11335