CBX3 Polyclonal Antibody

CAT: 0498-bs-53080RSize: 100 µLDry Ice: NoHazardous: No
CAT#:0498-bs-53080RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) . Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.
Synonyms
Chromobox protein homolog 3, CBX3, HECH, Heterochromatin protein 1 homolog gamma, HP1 gamma, Modifier 2 protein
Gene ID
11335
Swiss Prot
Q13185
Host
Rabbit
Cross Reactivity
Human
Target
CBX3
Clonality
Polyclonal
Conjugation
Unconjugated
Source
Polyclonal antibody raised in rabbit against human CBX3 using two KLH-conjugated synthetic peptides containing a sequence from the N-terminal and the central region of the protein, respectively
Applications
WB, ELISA
Purification
Whole antiserum from rabbit containing 0.05% azide
Concentration
Not Determined
Dilution
WB (1:300-5000), ELISA (1:500-1000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Store at -20°C for 12 months.
Gene ID URL
11335

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