Products for Research Use Only
RegisterLogin

Araguspongin B

CAT: 0804-HY-120985-01Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-120985-01Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties.1 Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores.2 Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC50 of 0.6 μM. It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.
CAS Number
123000-02-2
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/araguspongin-b.html
Smiles
[H][C@@]1(CCC2)[C@]3([H])N2CC[C@@](CCCCCC[C@@]4([H])[C@@]5([H])O[C@@](CCN5CCC4)([H])CCCCCC1)([H])C3
Molecular Formula
C29H52N2O
Molecular Weight
444.74
References & Citations
[1]Majerus, et al. Inositol phosphate biochemistry. Annu. Rev. Biochem. 61, 225-250 (1992) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

(+)-Xestospongin B
CAS Number123000-02-2
PubChem CID71771506
IUPAC Name(8S,10R,15R,22S,29R,32R)-32-methyl-9,30-dioxa-11,25-diazapentacyclo[20.6.2.28,11.010,15.025,29]dotriacontan-1-ol
Molecular FormulaC29H52N2O3
Molecular Weight476.7
XLogP6.6
Topological Polar Surface Area45.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count0
Heavy Atom Count34
Formal Charge0
Complexity632
SMILES
C[C@@H]1CN2CCC[C@@H]3[C@H]2O[C@H]1CCCCCCC4(CCCN5[C@@H]4O[C@@H](CCCCCC3)CC5)O
InChI
InChI=1S/C29H52N2O3/c1-23-22-31-19-10-13-24-12-6-2-3-7-14-25-16-21-30-20-11-18-29(32,28(30)33-25)17-9-5-4-8-15-26(23)34-27(24)31/h23-28,32H,2-22H2,1H3/t23-,24-,25+,26+,27-,28-,29?/m1/s1
InChIKey
VJEURJNEIZLTJG-BZFKMGMNSA-N
Chemical Structure
2D Structure
2D structure of (+)-Xestospongin B
CAS: 123000-02-2
CID: 71771506
Formula: C29H52N2O3
MW: 476.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight476.7
XLogP36.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count0
Exact Mass476.39779352
Monoisotopic Mass476.39779352
Topological Polar Surface Area45.2 Ų
Heavy Atom Count34
Formal Charge0
Complexity632
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-N3303Meliasenin B
HY-P5705Gageotetrin B
HY-P11334Cyanostatin B
HY-P10134Salivaricin B
HY-N8886Galanganone B
HY-N8261-01Amicoumacin B
HY-N7213Leonoside B
HY-N6174Heronapyrrole B
HY-N16645Plasiaticine B
HY-N16565Piperchabamide B

Alternative Products

CatalogName
sc-205215Araguspongin B

Popular Products