Amicoumacin B

• Description :

  Amicoumacin B can be produced by actinomycete, strain 04-5195T.. Amicoumacin B increases the expression of bone morphogenetic protein 2 (BMP-2) . Amicoumacin B has inhibitory effect against C. violaceum (MIC = 250 µg/mL) . Amicoumacin B has quorum sensing inhibitory activity, and reduces the expression of the C. violaceum operons vioA, vioB, vioD, and vioE, but increases the expression of vioC[1][2].

• UNSPSC :

  12352005

• Target :

  Bacterial; TGF-beta/Smad

• Related Pathways :

  Anti-infection; Stem Cell/Wnt; TGF-beta/Smad

• Field of Research :

  Infection

• Smiles :

  O=C1C2=C(O)C=CC=C2C[C@@](O1)([H])[C@H](CC(C)C)NC([C@@H](O)[C@@H](O)[C@@H](N)CC(O)=O)=O

• Molecular Formula :

  C20H28N2O8

• Molecular Weight :

  424.44

• References & Citations :

  [1]Shi WP, et al. Amicoumacins from a desert bacterium: quorum sensing inhibitor against Chromobacterium violaceum. Nat Prod Res. 2021 Dec;35 (23) :5508-5512.|[2]Sun W, et al. Nocardia jinanensis sp. nov., an amicoumacin B-producing actinomycete. Int J Syst Evol Microbiol. 2009 Feb;59 (Pt 2) :417-20.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [77674-99-8]