CBX3 Polyclonal Antibody

• Background:

  Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR) . Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.

• Synonyms:

  Chromobox protein homolog 3, CBX3, HECH, Heterochromatin protein 1 homolog gamma, HP1 gamma, Modifier 2 protein

• Gene ID:

  11335

• Swiss Prot:

  Q13185

• Host:

  Rabbit

• Cross Reactivity:

  Human

• Target:

  CBX3

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Source:

  Polyclonal antibody raised in rabbit against human CBX3 using two KLH-conjugated synthetic peptides containing a sequence from the N-terminal and the central region of the protein, respectively

• Applications:

  ELISA

• Purification:

  Whole antiserum from rabbit containing 0.05% azide

• Concentration:

  Not Determined

• Dilution:

  ELISA (1:500-1000)

• Buffer:

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Store at -20°C for 12 months.

• Gene ID URL:

  11335