Jarid1c Polyclonal Antibody

• Background:

  Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.

• Synonyms:

  KDM5C, MRXJ, MRXSJ, SMCX, XE169

• Gene ID:

  8242

• Swiss Prot:

  P41229

• Host:

  Rabbit

• Cross Reactivity:

  Human, Mouse

• Target:

  Jarid1c

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Source:

  Polyclonal antibody raised in rabbit against mouse Jarid1c (jumonji, AT rich interactive domain 1C), using 3 KLH-conjugated synthetic peptides containing sequences from the inner part of the protein

• Applications:

  WB, ELISA

• Purification:

  Whole antiserum from rabbit containing 0.05% azide

• Concentration:

  Not Determined

• Dilution:

  WB (1:300-5000), ELISA (1:500-1000)

• Buffer:

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Store at -20°C for 12 months.

• Gene ID URL:

  8242