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OST-beta Polyclonal Antibody

CAT: 0498-bs-42194RSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-42194RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor) . This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum.
Synonyms
Organic solute transporter beta (Ostbeta) ; Organic solute transporter subunit beta; Ostbeta; Ost beta; OSTB; OSTB_HUMAN.
Gene ID
123264
Swiss Prot
Q86UW2
Cellular Locus
Cell membrane
Host
Rabbit
Cross Reactivity
Human
Immunogen
57-128/128
Target
OST-beta
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
Recombinant human OST-beta protein
Applications
WB
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000)
Buffer
Aqueous buffered solution containing PBS with 0.02% sodium azide,50% glycerol, pH7.3.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
123264

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