Products for Research Use Only
RegisterLogin

ATG3 Polyclonal Antibody

CAT: 0498-bs-4013RSize: 100 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0498-bs-4013RSize:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) . The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE) . This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt) . Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
Synonyms
APG3; APG3L; PC3-96; APG3-LIKE; Ubiquitin-like-conjugating enzyme ATG3; Autophagy-related protein 3; hApg3; Protein PC3-96; ATG3
Gene ID
64422
Swiss Prot
Q9NT62
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Mouse
Immunogen
51-150/314
Target
ATG3
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human ATG3
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
64422
Predicted Cross Reactivity
Human, Rat, Dog, Cow, Pig, Horse, Chicken, Rabbit

Related Products

CatalogName
bs-5204RPhospho-ATG3 (Tyr18) Polyclonal Antibody
bsm-61474R-TRATG3 Recombinant Antibody
bsm-61474R-01ATG3 Recombinant Antibody
bs-5204R-FITCPhospho-ATG3 (Tyr18) Polyclonal Antibody, FITC Conjugated
bs-5204R-Cy3Phospho-ATG3 (Tyr18) Polyclonal Antibody, Cy3 Conjugated
bs-5204R-APCPhospho-ATG3 (Tyr18) Polyclonal Antibody, APC Conjugated
bs-5204R-HRPPhospho-ATG3 (Tyr18) Polyclonal Antibody, HRP Conjugated
bs-5204R-Cy5Phospho-ATG3 (Tyr18) Polyclonal Antibody, Cy5 Conjugated
bsm-51284MATG3 (7C2) Monoclonal Antibody
bs-5204R-RBITCPhospho-ATG3 (Tyr18) Polyclonal Antibody, RBITC Conjugated

Alternative Products

CatalogName
MBS9125555-01ATG3 Polyclonal Antibody
APG02036GPolyclonal ATG3 Antibody
GTR17880341ATG3 Rabbit Polyclonal Antibody
HV537014-01Anti-ATG3 Polyclonal Antibody

Popular Products