Chlorpheniramine-d6

• Description:

  Chlorpheniramine-d6 (Chlorphenamine-d6) is deuterium labeled Chlorpheniramine. Chlorpheniramine is a H1 antihistamines commonly used in allergic diseases research[1][2].

• Product Name Alternative:

  Chlorphenamine-d6

• UNSPSC:

  12352005

• Target:

  Histamine Receptor; Isotope-Labeled Compounds

• Related Pathways:

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  [2H]C([2H])([2H])N(C([2H])([2H])[2H])CCC(C1=CC=CC=N1)C2=CC=C(C=C2)Cl

• Molecular Formula:

  C16H13D6ClN2

• Molecular Weight:

  280.83

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Jiwon Kim, etal. Inhibitory effects of antihistamines, diphenhydramine and chlorpheniramine, on proton currents in BV2 microglial cells. Eur J Pharmacol. 2017 Mar 5;798:122-128.|[3]Kyung-Jin Jung, etal. Enhancement of B cell and monocyte populations in rats exposed to chlorpheniramine. Arch Pharm Res. 2012 Dec;35 (12) :2183-9.|[4]Takano, N., I. Arai, and M. Kurachi, Analysis of the spontaneous scratching behavior by NC/Nga mice: a possible approach to evaluate antipruritics for subjects with atopic dermatitis. Eur J Pharmacol, 2003. 471 (3) : p. 223-8.|[5]Kelly, J.X., et al., Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum. Antimicrob Agents Chemother, 2007. 51 (11) : p. 4133-40.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [1185054-60-7]