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Methylproamine

CAT: 0804-HY-15620-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-15620-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA. Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks[1].
CAS Number
188247-01-0
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Biochemical Assay Reagents
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Methylproamine.html
Purity
98.90
Solubility
DMSO : ≥ 41 mg/mL
Smiles
CN1CCN(C2=CC=C3C(N=C(C4=CC=C5C(N=C(C6=CC=C(N(C)C)C=C6C)N5)=C4)N3)=C2)CC1
Molecular Formula
C28H31N7
Molecular Weight
465.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Lobachevsky PN, Vasireddy RS, Broadhurst S, Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol. 2011 Mar;87 (3) :274-83.|[2]Sprung CN, Vasireddy RS, Karagiannis TC, Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks. Mutat Res. 2010 Oct 13;692 (1-2) :49-52.|[3]Martin RF, Broadhurst S, Reum ME, In vitro studies with methylproamine: a potent new radioprotector. Cancer Res. 2004 Feb 1;64 (3) :1067-70.|[4]Carl N Sprung, et al. Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks.|[5]Susanne Burdak-Rothkamm, et al. Radioprotection of targeted and bystander cells by methylproamine. Strahlenther Onkol. 2015 Mar;191 (3) :248-55.|[6]Pavel N Lobachevsky, et al. Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol. 2011 Mar;87 (3) :274-83.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

Chemical Information

Methylproamine

a radioprotective agent; structure in first source

CAS Number188247-01-0
PubChem CID448201
IUPAC NameN,N,3-trimethyl-4-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]aniline
Molecular FormulaC28H31N7
Molecular Weight465.6
XLogP4.8
Topological Polar Surface Area67.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count35
Formal Charge0
Complexity709
SMILES
CC1=C(C=CC(=C1)N(C)C)C2=NC3=C(N2)C=C(C=C3)C4=NC5=C(N4)C=C(C=C5)N6CCN(CC6)C
InChI
InChI=1S/C28H31N7/c1-18-15-20(33(2)3)6-8-22(18)28-30-23-9-5-19(16-25(23)32-28)27-29-24-10-7-21(17-26(24)31-27)35-13-11-34(4)12-14-35/h5-10,15-17H,11-14H2,1-4H3,(H,29,31)(H,30,32)
InChIKey
ADKLMOJIJGHCCD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Methylproamine
CAS: 188247-01-0
CID: 448201
Formula: C28H31N7
MW: 465.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight465.6
XLogP34.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass465.26409402
Monoisotopic Mass465.26409402
Topological Polar Surface Area67.1 Ų
Heavy Atom Count35
Formal Charge0
Complexity709
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA4026-50Methylproamine
A15160-200Methylproamine 200mg
A15160-5Methylproamine 5mg
A15160-100Methylproamine 100mg
A15160-50Methylproamine 50mg
A15160-25Methylproamine 25mg
A15160-10Methylproamine 10mg
A15160-10mM-DMethylproamine 10mM * 1mL in DMSO

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