Methylproamine

• Description :

  Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA. Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks[1].

• UNSPSC :

  12352200

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  DNA/RNA Synthesis

• Type :

  Biochemical Assay Reagents

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/Methylproamine.html

• Purity :

  98.90

• Solubility :

  DMSO : ≥ 41 mg/mL

• Smiles :

  CN1CCN(C2=CC=C3C(N=C(C4=CC=C5C(N=C(C6=CC=C(N(C)C)C=C6C)N5)=C4)N3)=C2)CC1

• Molecular Formula :

  C28H31N7

• Molecular Weight :

  465.59

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Lobachevsky PN, Vasireddy RS, Broadhurst S, Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol. 2011 Mar;87 (3) :274-83.|[2]Sprung CN, Vasireddy RS, Karagiannis TC, Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks. Mutat Res. 2010 Oct 13;692 (1-2) :49-52.|[3]Martin RF, Broadhurst S, Reum ME, In vitro studies with methylproamine: a potent new radioprotector. Cancer Res. 2004 Feb 1;64 (3) :1067-70.|[4]Carl N Sprung, et al. Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks.|[5]Susanne Burdak-Rothkamm, et al. Radioprotection of targeted and bystander cells by methylproamine. Strahlenther Onkol. 2015 Mar;191 (3) :248-55.|[6]Pavel N Lobachevsky, et al. Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol. 2011 Mar;87 (3) :274-83.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Biochemical Assay Reagents

• Clinical Information :

  No Development Reported

• CAS Number :

  [188247-01-0]