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Methylproamine

CAT: 0804-HY-15620-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15620-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Methylproamine is a DNA-binding radioprotector, acts by repair of transient radiation-induced oxidative species on DNA. Methylproamine also protects against ionizing radiation by preventing DNA double-strand breaks[1].
CAS Number
188247-01-0
UNSPSC
12352200
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis
Type
Biochemical Assay Reagents
Related Pathways
Cell Cycle/DNA Damage
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/Methylproamine.html
Purity
98.90
Solubility
DMSO : ≥ 41 mg/mL
Smiles
CN1CCN(C2=CC=C3C(N=C(C4=CC=C5C(N=C(C6=CC=C(N(C)C)C=C6C)N5)=C4)N3)=C2)CC1
Molecular Formula
C28H31N7
Molecular Weight
465.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Lobachevsky PN, Vasireddy RS, Broadhurst S, Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol. 2011 Mar;87 (3) :274-83.|[2]Sprung CN, Vasireddy RS, Karagiannis TC, Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks. Mutat Res. 2010 Oct 13;692 (1-2) :49-52.|[3]Martin RF, Broadhurst S, Reum ME, In vitro studies with methylproamine: a potent new radioprotector. Cancer Res. 2004 Feb 1;64 (3) :1067-70.|[4]Carl N Sprung, et al. Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks.|[5]Susanne Burdak-Rothkamm, et al. Radioprotection of targeted and bystander cells by methylproamine. Strahlenther Onkol. 2015 Mar;191 (3) :248-55.|[6]Pavel N Lobachevsky, et al. Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol. 2011 Mar;87 (3) :274-83.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Biochemical Assay Reagents
Clinical Information
No Development Reported

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