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J 104871

CAT: 0804-HY-19301Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-19301Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
J 104871 (J-104135) is a farnesyl pyrophosphate (FPP) -competitive farnesyltransferase (FTase) inhibitor. J 104871 inhibits rat brain FTase with an IC50 of 3.9 nM in the presence of farnesyl pyrophosphate (FPP) [1].
CAS Number
191088-19-4
Product Name Alternative
J-104135
UNSPSC
12352005
Target
Farnesyl Transferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/j-104871.html
Smiles
O=C(C1(C(O)=O)O[C@H](C(N([C@H](C)[C@@H](C2=CC=C(OCO3)C3=C2)C/C=C/C4=NC5=CC=CC=C5O4)CC6=CC=C7C=CC=CC7=C6)=O)[C@H](C(O)=O)O1)O
Molecular Formula
C38H32N2O12
Molecular Weight
708.67
References & Citations
[1]M Yonemoto, et al. J-104,871, a novel farnesyltransferase inhibitor, blocks Ras farnesylation in vivo in a farnesyl pyrophosphate-competitive manner. Mol Pharmacol. 1998 Jul;54 (1) :1-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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