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BBO-10203

CAT: 0957-E5872-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0957-E5872-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BBO-10203 inhibits PI3Kα and KRASG12C by covalently binding to Cys242 in the PI3Kα RAS-Binding Domain. It inhibits both GTP-bound and GDP-bound KRASG12C states, with IC50 and EC50 values of 0.031 nM and 0.02 nM respectively. This compound interferes with RAS-PI3Kα interaction, suppressing RAS-dependent PI3Kα activation. It decreases pERK levels, inhibits cell proliferation, and causes G1 phase arrest and apoptosis. BBO-10203 has potential applications in breast cancer, colorectal cancer, and non-small cell lung cancer research.
CAS Number
2971769-60-3
Target
PI3K
Activity
PI3K/Akt/mTOR
Molecular Formula
C34H30F2N6O3S
Storage Conditions
3 years-20°C powder 2 years-80°C in solvent

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