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Stattic

CAT: 0957-S7024-02Size: 10 mm/ 1 mLDry Ice: YesHazardous: No
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CAT#:0957-S7024-02Size:10 mm/ 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Stattic, the first nonpeptidic small molecule, potently inhibits STAT3 activation and nuclear translocation with IC50 of 5.1 μM in cell-free assays, highly selectivity over STAT1. Stattic induces apoptosis.
CAS Number
19983-44-9
Target
STAT
Activity
Apoptosis
Molecular Formula
C8H5NO4S
Storage Conditions
2 years -80 in solvent

Chemical Information

Stattic

Stattic is a member of the class of 1-benzothiophenes that is 1-benzothiophene-1,1-dioxide substituted at position 6 by a nitro group. Used as a radiosensitising agent for esophageal squamous cell carcinoma. It has a role as a radiosensitizing agent, an antineoplastic agent and a STAT3 inhibitor. It is a C-nitro compound, a sulfone and a member of 1-benzothiophenes.

CAS Number19983-44-9
PubChem CID2779853
IUPAC Name6-nitro-1-benzothiophene 1,1-dioxide
Molecular FormulaC8H5NO4S
Molecular Weight211.20
XLogP0.7
Topological Polar Surface Area88.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Heavy Atom Count14
Formal Charge0
Complexity375
SMILES
C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]
InChI
InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H
InChIKey
ZRRGOUHITGRLBA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Stattic
CAS: 19983-44-9
CID: 2779853
Formula: C8H5NO4S
MW: 211.20
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight211.20
XLogP30.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Exact Mass210.99392881
Monoisotopic Mass210.99392881
Topological Polar Surface Area88.3 Ų
Heavy Atom Count14
Formal Charge0
Complexity375
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A2224-100Stattic

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