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MPP+ iodide

CAT: 0957-S6301-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-S6301-01Size:5 mg
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Description
MPP+ iodide (N-Methyl-4-Phenylpyridinium Iodide), the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces autophagic cell death in SH-SY5Y cells. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons.
CAS Number
36913-39-0
Synonyms
N-Methyl-4-Phenylpyridinium Iodide
Target
Autophagy
Activity
Autophagy
Molecular Formula
C12H12IN
Storage Conditions
3 years-20°C (in the dark) powder

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