Products for Research Use Only
RegisterLogin

Dematin Polyclonal Antibody

CAT: 0498-bs-20187RSize: 100 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0498-bs-20187RSize:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA) . Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.
Synonyms
DMT; EPB49; Dematin; Dematin actin-binding protein; Erythrocyte membrane protein band 4.9; DMTN
Gene ID
2039
Swiss Prot
Q08495
Cellular Locus
Cytoplasm, Cell membrane
Host
Rabbit
Cross Reactivity
Human
Immunogen
201-300/405
Target
Dematin
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human Dematin
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
2039

Related Products

CatalogName
bs-8563R-01KIAA1522 Polyclonal Antibody
bs-8560RELL3 Polyclonal Antibody
bs-8557RDSPP Polyclonal Antibody
bs-8545RTRAF4 Polyclonal Antibody
bs-8539R-01Luciferase Polyclonal Antibody
bs-8537RTYMS Polyclonal Antibody
bs-8518R-01SPP24 Polyclonal Antibody
bs-8514R-01FCER1A Polyclonal Antibody
bs-8500RRFTN2 Polyclonal Antibody
bs-8497RRENBP Polyclonal Antibody

Alternative Products

CatalogName
MBS8522306-01Dematin Polyclonal Antibody
NBP1-85007Rabbit Polyclonal Dematin Antibody
E28PT1325Dematin Rabbit Polyclonal Antibody
H00002039-B01PMouse Polyclonal Dematin Antibody
TMAB-05078-01Anti-Dematin Polyclonal Antibody
UB-GEN-2975Dematin (phospho Ser403) Polyclonal Antibody
TA373077Dematin (DMTN) Rabbit Polyclonal Antibody
GTR17715734Dematin Rabbit Polyclonal Antibody (HRP)
GTR17754116Dematin Rabbit Polyclonal Antibody (FITC)
GTR18463985Dematin Rabbit Polyclonal Antibody (BF680)

Popular Products