DSPP Polyclonal Antibody

• Background:

  DSPP may be an important factor in dentinogenesis. DSPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.The dentin sialophosphoprotein (DSPP) gene encodes two major noncollagenous dentin matrix proteins: dentin sialoprotein, known as DSP; and dentin phosphoprotein, known as phosphophoryn or DPP. The DSPP gene maps to human chromosome 4 and yields a 4.6 kb transcript containing 5 exons, with exons 1-4 encoding for DSP and exon 5 encoding for both the C-terminus of DSP and the full length DPP. DPP and DSP are acidic proteins that represent about 50% of the noncollagenous proteins in the dentin extracellular matrix of teeth. The DSPP gene is a likely candidate gene for the genetic diseases associated with abnormal dentin formation such as dentinogenesis imperfecta type II and dentin dysplasia type II. DPP may bind large amounts of calcium and may facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.

• Synonyms:

  Dentin phosphophoryn; Dentin phosphoprotein; dentin phosphoryn; Dentin sialophosphoprotein; Dentin sialophosphoprotein precursor; Dentin sialoprotein; dentinogenesis imperfecta 1; DFNA39; DGI1; DMP3; DPP; DSP; Dspp; DSPP_HUMAN; DTDP2.

• Gene ID:

  1834

• Host:

  Rabbit

• Cross Reactivity:

  Human, Mouse, Rat

• Target:

  DSPP

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  Unconjugated

• Source:

  KLH conjugated synthetic peptide derived from human DSPP/Dentin phosphophoryn

• Applications:

  WB, IHC-P, IHC-F, IF

• Purification:

  Purified by Protein A.

• Concentration:

  1µg/µl

• Dilution:

  WB (WB=1:500-2000), IHC-P (IHC-P=1:100-500), IHC-F (IHC-F=1:100-500), IF (IF=1:100-500)

• Buffer:

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Store at -20°C for 12 months.

• Gene ID URL:

  1834