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Sepantronium Bromide (YM155)

CAT: 0957-S1130-01Size: 5 mgDry Ice: YesHazardous: No
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CAT#:0957-S1130-01Size:5 mg
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Description
Sepantronium Bromide (YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.
CAS Number
781661-94-7
Target
Survivin
Activity
Apoptosis
Molecular Formula
C20H19BrN4O3
Storage Conditions
2 years -80 in solvent

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