DNASE1L2 Polyclonal Antibody, Cy3 Conjugated

• Background:

  DNASE1L2 is a 299 amino acid secreted protein that is expressed in brain tissue and shares sequence similarity with DNase I, suggesting a possibly role in DNA hydrolysis. The gene encoding DNASE1L2 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.

• Synonyms:

  Deoxyribonuclease I-like 2; Deoxyribonuclease-1-like 2; DNase I homolog protein DHP1; DNase I-like 2; Dnase1l2; DNSL2_HUMAN.

• Gene ID:

  1775

• Swiss Prot:

  Q92874

• Cellular Locus:

  Cytoplasm

• Host:

  Rabbit

• Cross Reactivity:

  Rat

• Immunogen:

  201-299/299

• Target:

  DNASE1L2

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Conjugation:

  Cy3

• Source:

  KLH conjugated synthetic peptide derived from human DNASE1L2

• Applications:

  IF (IHC-P), IF (IHC-F), IF (ICC)

• Purification:

  Purified by Protein A.

• Excitation Emission:

  512,550nm/570,615nm

• Concentration:

  1µg/µl

• Dilution:

  IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

• Buffer:

  Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

• Gene ID URL:

  1775

• Predicted Cross Reactivity:

  Human, Mouse, Cow, Sheep, Pig, Horse, Rabbit