DRIP130 Polyclonal Antibody

CAT: 0498-bs-13032RSize: 100 µLDry Ice: NoHazardous: No
CAT#:0498-bs-13032RSize:100 µL
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Background
In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signals between transcriptional activators and RNA polymerase (1) . These complexes include CRSP (for cofactor required for Sp1 activation), which is required, in conjunction with TAFIIs, for transcriptional activation by Sp1 (2) . CRSP is ubiquitously expressed in various tissues and functions as a multimeric complex that consists of nine distinct subunits (3) . Several members of the CRSP family share sequence similarity with multiple components of the yeast transcriptional mediator proteins, including CRSP150, which is related to yeast Rgr1, and CRSP70, which is similar to the elongation factor TFIIS (4) . CRSP77 and CRSP150 are also related to proteins within the putative murine mediator complex, while CRSP130 and CRSP34 are largely unrelated to either murine or yeast proteins (2,5) . CRSP subunits also associate with larger multimeric coactivaor complexes, including ARC/DRI, which binds directly to SREBP and nuclear hormone receptors to facilitate transcription, and with NAT, a polymerase II-interacting complex that represses activated transcription (6,7) .
Synonyms
130 kDa transcriptional co activator; 133 kDa transcriptional co activator; Activator recruited cofactor 130 kDa component; Activator-recruited cofactor 130 kDa component; ARC 130; ARC130; Cofactor required for Sp1 transcriptional activation subunit 3 130kDa; Cofactor required for Sp1 transcriptional activation subunit 3 130kDa mediator; Cofactor required for Sp1 transcriptional activation subunit 3; CRSP 130; CRSP 130 kD subunit; CRSP 133; CRSP 3; CRSP complex subunit 3; CRSP130; CRSP133; CRSP3; CRSP3 protein; DKFZp434H0117; DRIP 130; DRIP130; hSur-2; KIAA1216; MED 23; MED23; MED23_HUMAN; Mediator complex subunit 23; Mediator of RNA polymerase II transcription subunit 23; Protein sur-2 homolog; SUR 2; SUR2; Transcriptional co activator CRSP 130; Transcriptional co activator CRSP130; Transcriptional coactivator CRSP130; Vitamin D3 receptor interacting protein; Vitamin D3 receptor interacting protein complex 130 kDa component; Vitamin D3 receptor-interacting protein complex 130 kDa component.
Gene ID
9439
Cellular Locus
Nucleus
Host
Rabbit
Immunogen
401-500/1368
Target
DRIP130
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human DRIP130/CRSP130
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
9439
Predicted Cross Reactivity
Human, Mouse

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