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Vanzacaftor

CAT: 0957-E1701-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-E1701-02Size:5 mg
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Description
Vanzacaftor (VX-121) is an orally active corrector of Cystic fibrosis transmembrane conductance regulator (CFTR) . Vanzacaftor improves the processing and trafficking of CFTR protein and increases chloride transport in combination with Tezacaftor and Deutivacaftor.
CAS Number
2374124-49-7
Synonyms
VX-121
Target
CFTR
Activity
Transmembrane Transporters
Molecular Formula
C32H39N7O4S

Chemical Information

Vanzacaftor

Vanzacaftor is a small molecule cystic fibrosis transmembrane conductance regulator (CFTR) corrector. It is used alongside other CFTR correctors and CFTR potentiators to increase the quantity and function of CFTR at the cell surface in patients with cystic fibrosis. Vanzacaftor was first approved by the US FDA in December 2024 in combination with another CFTR corrector - [tezacaftor], which binds to a different site than vanzacaftor - and [deutivacaftor], a CFTR potentiator, for the treatment of patients with responsive CFTR mutations.

CAS Number2374124-49-7
PubChem CID139399801
IUPAC Name(14S)-8-[3-(2-dispiro[2.0.24.13]heptan-7-ylethoxy)pyrazol-1-yl]-12,12-dimethyl-2,2-dioxo-2lambda6-thia-3,9,11,18,23-pentazatetracyclo[17.3.1.111,14.05,10]tetracosa-1(22),5(10),6,8,19(23),20-hexaen-4-one
Molecular FormulaC32H39N7O4S
Molecular Weight617.8
XLogP5.7
Topological Polar Surface Area140
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Heavy Atom Count44
Formal Charge0
Complexity1200
SMILES
CC1(C[C@@H]2CCCNC3=NC(=CC=C3)S(=O)(=O)NC(=O)C4=C(N1C2)N=C(C=C4)N5C=CC(=N5)OCCC6C7(C68CC8)CC7)C
InChI
InChI=1S/C32H39N7O4S/c1-30(2)19-21-5-4-16-33-24-6-3-7-27(34-24)44(41,42)37-29(40)22-8-9-25(35-28(22)38(30)20-21)39-17-10-26(36-39)43-18-11-23-31(12-13-31)32(23)14-15-32/h3,6-10,17,21,23H,4-5,11-16,18-20H2,1-2H3,(H,33,34)(H,37,40)/t21-/m0/s1
InChIKey
VCSUIBJKYCVWNF-NRFANRHFSA-N
Chemical Structure
2D Structure
2D structure of Vanzacaftor
CAS: 2374124-49-7
CID: 139399801
Formula: C32H39N7O4S
MW: 617.8
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight617.8
XLogP35.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass617.27842392
Monoisotopic Mass617.27842392
Topological Polar Surface Area140 Ų
Heavy Atom Count44
Formal Charge0
Complexity1200
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BUP23976-01Vanzacaftor
T84699-01(R) -Vanzacaftor
HY-145603SVanzacaftor-d4

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