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ARV-766

CAT: 0957-E1573-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-E1573-02Size:25 mg
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Description
Luxdegalutamide (ARV-766) is an orally active and potent degrader of proteolysis targeting chimera (PROTAC) protein. ARV-766 degrades wild-type androgen receptor (AR) but also relevant AR LBD mutants, including the most prevalent AR L702H, H875Y, and T878A mutations.
CAS Number
2750830-09-0
Synonyms
Luxdegalutamide
Target
PROTAC
Activity
Others
Molecular Formula
C45H54FN7O6

Chemical Information

Luxdegalutamide

JSB462 is under investigation in clinical trial NCT07047118 (A Study of JSB462 (Luxdegalutamide) Plus Lutetium (177Lu) Vipivotide Tetraxetan in Patients With Metastatic Castration Resistant Prostate Cancer (mCRPC)).

CAS Number2750830-09-0
PubChem CID156504141
IUPAC Name4-[4-[[1-[4-[[3-(4-cyano-3-methoxyphenoxy)-2,2,4,4-tetramethylcyclobutyl]carbamoyl]phenyl]piperidin-4-yl]methyl]piperazin-1-yl]-N-[(3S)-2,6-dioxopiperidin-3-yl]-2-fluorobenzamide
Molecular FormulaC45H54FN7O6
Molecular Weight808.0
XLogP5.9
Topological Polar Surface Area156
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count11
Heavy Atom Count59
Formal Charge0
Complexity1550
SMILES
CC1(C(C(C1OC2=CC(=C(C=C2)C#N)OC)(C)C)NC(=O)C3=CC=C(C=C3)N4CCC(CC4)CN5CCN(CC5)C6=CC(=C(C=C6)C(=O)N[C@H]7CCC(=O)NC7=O)F)C
InChI
InChI=1S/C45H54FN7O6/c1-44(2)42(45(3,4)43(44)59-33-12-8-30(26-47)37(25-33)58-5)50-39(55)29-6-9-31(10-7-29)52-18-16-28(17-19-52)27-51-20-22-53(23-21-51)32-11-13-34(35(46)24-32)40(56)48-36-14-15-38(54)49-41(36)57/h6-13,24-25,28,36,42-43H,14-23,27H2,1-5H3,(H,48,56)(H,50,55)(H,49,54,57)/t36-,42?,43?/m0/s1
InChIKey
RDPPBRKNBBXPNZ-PJXMSJPKSA-N
Chemical Structure
2D Structure
2D structure of Luxdegalutamide
CAS: 2750830-09-0
CID: 156504141
Formula: C45H54FN7O6
MW: 808.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight808.0
XLogP35.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count11
Rotatable Bond Count11
Exact Mass807.41196063
Monoisotopic Mass807.41196063
Topological Polar Surface Area156 Ų
Heavy Atom Count59
Formal Charge0
Complexity1550
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
C01741-01ARV-766
A24577-50Luxdegalutamide (ARV-766) 50mg
A24577-10Luxdegalutamide (ARV-766) 10mg
A24577-5Luxdegalutamide (ARV-766) 5mg
A24577-1Luxdegalutamide (ARV-766) 1mg
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BA4656-5.1ARV-771
BA5849-5ARV-393
EPD71168-01ARV-471
MBS3613655-01ARV-110

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