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APOL1 Polyclonal Antibody

CAT: 0498-bs-12498RSize: 100 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-12498RSize:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Apolipoproteins are protein components of plasma lipoproteins (1) . The apolipoprotein L gene family encodes six highly homologous proteins designated apoL-I to -VI, which are associated with large high density type lipoproteins (HDL) (2,3) . The human apoL family maps to chromosome 22q12.1-13.1 within a 127,000-bp region (4) . ApoL has been characterized as a pancreas specific, 383-amino acid protein that contains a 12-amino acid secretory signal peptide (4) . The apoL genes have TATA-less promoters and contain putative sterol regulatory elements, suggesting that transcription of these genes may be coordinated with that of the low density lipoprotein receptor and genes in pathways involving the synthesis of triglycerides and cholesterol (3) . ApoL homologs can undergo 10 fold changes in expression during atherosclerotic changes in vascular endothelial cells, which includes the inflammatory reaction of atherosclerotic lesions (5) .
Synonyms
APO L; Apo-L; APOL; APOL I; ApoL-I; APOL1; Apolipoprotein L1; APOL1_HUMAN; APOLI; APOL1; APOL 1; APOL-1; Apolipoprotein L; Apolipoprotein L I; Apolipoprotein L-I; Apolipoprotein L1; Apolipoprotein L-1; FSGS4.
Gene ID
8542
Cellular Locus
Secreted
Host
Rabbit
Cross Reactivity
Human
Immunogen
201-300/398
Target
APOL1
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human APOL1/Apolipoprotein L
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Gene ID URL
8542

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