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Terfenadine

CAT: 0957-S4353Size: 25 mgDry Ice: YesHazardous: No
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CAT#:0957-S4353Size:25 mg
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Description
Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform. Terfenadine ((±) -Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9.
CAS Number
50679-08-8
Target
Potassium Channel
Activity
Transmembrane Transporters
Molecular Formula
C32H41NO2
Storage Conditions
2 years -80 in solvent

Alternative Products

CatalogName
MBS6106930-01Terfenadine

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