FOXD1 Polyclonal Antibody

CAT: 0498-bs-12193RSize: 100 µLDry Ice: NoHazardous: No
CAT#:0498-bs-12193RSize:100 µL
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Background
Transcription factor required for formation of positional identity in the developing retina, regionalization of the optic chiasm and morphogenesis of the kidney. Can neuralize ectodermal cells directly By similarity. Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Probable transcription factor involved in embryogenesis and somatogenesis. FOXD1 is involved in regulating inflammation as well as kidney and retinal development. FOXD1 regulates the activity of NFAT and NFkB. Deficiency of FOXD1 results in multiorgan systemic inflammation, exaggerated Th cell-derived cytokine production, and T cell proliferation in autogolgous MLRs. In kidneys, FOXD1 controls the production of signals required for the normal transition of induced mesenchyme into tubular epithelium and full growth and branching of the collecting system. Deletion of FOXD1 results in renal abnormalities. FOXD2 acts as a modulator of T cell activation.
Synonyms
Forkhead box protein D1; Forkhead-related protein FKHL8; Forkhead-related transcription factor 4; FREAC-4Forkhead box protein D2; Forkhead-related protein FKHL17; Forkhead-related transcription factor 9; FREAC-9; FOXD3; FOXD1Forkhead box protein D4; Forkhead-related protein FKHL9; Forkhead-related transcription factor 5; FREAC-5; HNF3/FH transcription factor genesis.
Gene ID
2297, 2298, 27022, 2306
Swiss Prot
Q16676
Cellular Locus
Nucleus
Host
Rabbit
Immunogen
131-230/465
Target
FOXD1
Clonality
Polyclonal
Isotype
IgG
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human FOXD1
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1µg/µl
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Specificity
This antibody is useful for detecting the total expression level FOXD1, 2, 3 and 4.
Gene ID URL
2297, 2298, 27022, 2306
Predicted Cross Reactivity
Human, Mouse, Dog, Sheep, Chicken, Rabbit

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