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MASM7

CAT: 0957-E5826-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-E5826-01Size:5 mg
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Description
MASM7 is an activator of mitofusins that promotes mitochondrial fusion through mitofusins. It increases mitochondrial AR in MEFs in a concentration-dependent manner, with an EC50 value of 75 nM. MASM7 also directly binds to the HR2 domain of MFN2 with a dissociation constant (Kd) of 1.1 μM, effectively activating MFN2 or MFN to induce fusion.
CAS Number
920868-45-7
Target
Mitochondrial Metabolism
Activity
Metabolism
Molecular Formula
C22H23N5O2S2

Chemical Information

2-(2-((5-cyclopropyl-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)propanamido)-4H,5H,6H-cyclopenta(b)thiophene-3-carboxamide
CAS Number920868-45-7
PubChem CID16347380
IUPAC Name2-[2-[(5-cyclopropyl-4-phenyl-1,2,4-triazol-3-yl)sulfanyl]propanoylamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
Molecular FormulaC22H23N5O2S2
Molecular Weight453.6
XLogP3.9
Topological Polar Surface Area156
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count31
Formal Charge0
Complexity687
SMILES
CC(C(=O)NC1=C(C2=C(S1)CCC2)C(=O)N)SC3=NN=C(N3C4=CC=CC=C4)C5CC5
InChI
InChI=1S/C22H23N5O2S2/c1-12(20(29)24-21-17(18(23)28)15-8-5-9-16(15)31-21)30-22-26-25-19(13-10-11-13)27(22)14-6-3-2-4-7-14/h2-4,6-7,12-13H,5,8-11H2,1H3,(H2,23,28)(H,24,29)
InChIKey
MTAWXPCGCQTSOJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(2-((5-cyclopropyl-4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl)propanamido)-4H,5H,6H-cyclopenta(b)thiophene-3-carboxamide
CAS: 920868-45-7
CID: 16347380
Formula: C22H23N5O2S2
MW: 453.6
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight453.6
XLogP33.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass453.12931734
Monoisotopic Mass453.12931734
Topological Polar Surface Area156 Ų
Heavy Atom Count31
Formal Charge0
Complexity687
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BUP03989-01MASM7

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