G140

CAT: 0957-S9945-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0957-S9945-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

G140 is a potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS), with IC50s of 14.0 nM and 442 nM for h-cGAS and m-cGAS, respectively.

CAS Number

2369751-07-3

Target

CGAS

Activity

Autophagy

Molecular Formula

C17H16Cl2N4O2

Storage Conditions

3 years -20°C powder

Chemical Information

1-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-3,4-dihydro-1H-pyrido[4,3-b]indol-2(5H)-yl)-2-hydroxyethanone

CAS Number	2369751-07-3
PubChem CID	139388865
IUPAC Name	1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-hydroxyethanone
Molecular Formula	C17H16Cl2N4O2
Molecular Weight	379.2
XLogP	2
Topological Polar Surface Area	74.2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Heavy Atom Count	25
Formal Charge	0
Complexity	525

SMILES

CN1C=CC(=N1)C2=CC(=C(C3=C2C4=C(N3)CCN(C4)C(=O)CO)Cl)Cl

InChI

InChI=1S/C17H16Cl2N4O2/c1-22-4-2-13(21-22)9-6-11(18)16(19)17-15(9)10-7-23(14(25)8-24)5-3-12(10)20-17/h2,4,6,20,24H,3,5,7-8H2,1H3

InChIKey

NVPFAXHXXODQRO-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2369751-07-3

CID: 139388865

Formula: C17H16Cl2N4O2

MW: 379.2

Interactive 3D Structure

Loading 3D structure...

Computed Properties

Property	Value
Molecular Weight	379.2
XLogP3	2
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	2
Exact Mass	378.0650312
Monoisotopic Mass	378.0650312
Topological Polar Surface Area	74.2 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	525
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Catalog	Name
BA5949-10	G140
BS1615	Caspase 9 (G140) polyclonal antibody