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HM43239

CAT: 0957-S9892-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-S9892-01Size:5 mg
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Description
HM43239 is a novel potent small molecule FLT3 inhibitor that selectively inhibits not only FLT3 wild type, ITD mutants or TKD mutations, but also FLT3 ITD/TKD double mutations. IC50s’ of HM43239 against FLT3 WT, FLT3 ITD and FLT3 D835Y kinases are 1.1 nM, 1.8 nM and 1.0 nM, respectively.
CAS Number
2569527-64-4
Target
FLT3
Activity
Protein Tyrosine Kinase
Molecular Formula
C29H33ClN6
Storage Conditions
3 years -20°C powder

Chemical Information

Tuspetinib

Tuspetinib (HM-43239) is under investigation in clinical trial NCT03850574 (Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM43239 in Patients With Relapsed or Refractory Acute Myeloid Leukemia).

CAS Number2569527-64-4
PubChem CID135390910
IUPAC Name5-chloro-N-[3-cyclopropyl-5-[[(3S,5R)-3,5-dimethylpiperazin-1-yl]methyl]phenyl]-4-(6-methyl-1H-indol-3-yl)pyrimidin-2-amine
Molecular FormulaC29H33ClN6
Molecular Weight501.1
XLogP5.8
Topological Polar Surface Area68.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count36
Formal Charge0
Complexity725
SMILES
C[C@@H]1CN(C[C@@H](N1)C)CC2=CC(=CC(=C2)NC3=NC=C(C(=N3)C4=CNC5=C4C=CC(=C5)C)Cl)C6CC6
InChI
InChI=1S/C29H33ClN6/c1-17-4-7-24-25(12-31-27(24)8-17)28-26(30)13-32-29(35-28)34-23-10-20(9-22(11-23)21-5-6-21)16-36-14-18(2)33-19(3)15-36/h4,7-13,18-19,21,31,33H,5-6,14-16H2,1-3H3,(H,32,34,35)/t18-,19+
InChIKey
FZLSDZZNPXXBBB-KDURUIRLSA-N
Chemical Structure
2D Structure
2D structure of Tuspetinib
CAS: 2569527-64-4
CID: 135390910
Formula: C29H33ClN6
MW: 501.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight501.1
XLogP35.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass500.2455228
Monoisotopic Mass500.2455228
Topological Polar Surface Area68.9 Ų
Heavy Atom Count36
Formal Charge0
Complexity725
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS3617202-01HM43239
M37626-01HM43239 B

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