HM43239 B

CAT: 1410-M37626-01Size: 1 gDry Ice: NoHazardous: No
CAT#:1410-M37626-01Size:1 g
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Description
HM43239 is an orally active and selective FLT3 inhibitor with IC 50 s of 1.1 nM, 1.8 nM and 1.0 nM for FLT3 WT, FLT3 internal tandem duplication (ITD) and FLT3 D835Y kinases, respectively. HM43239 directly inhibits the kinase activity of FLT3 as a reversible Type I inhibitor and effectively modulates downstream p-STAT5 and p-ERK. HM43239 also demonstrated inhibition of SYK, JAK1/2 and TAK1. HM43239 inhibits the proliferation and induces the apoptosis of leukemic cells .
CAS Number
2294874-49-8
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
501.07
Molecular Formula
C29H33ClN6
Notes
Research use only, not for human use.
Receptor
FLT

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MBS3617202-01HM43239

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