GCN2iB

CAT: 0957-S8929-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0957-S8929-01Size:5 mg

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Description

GCN2iB is an ATP-competitive serine/threonine-protein kinase general control nonderepressible 2 (GCN2) inhibitor with IC50 of 2.4 nM.

CAS Number

2183470-12-2

Target

Serine/threonin kinase

Activity

Cell Cycle

Molecular Formula

C18H12ClF2N5O3S

Storage Conditions

3 years -20°C powder

Chemical Information

Gcn2iB

an ATP-competitive inhibitor of Gcn2 protein kinase

CAS Number	2183470-12-2
PubChem CID	134814489
IUPAC Name	N-[3-[2-(2-aminopyrimidin-5-yl)ethynyl]-2,4-difluorophenyl]-5-chloro-2-methoxypyridine-3-sulfonamide
Molecular Formula	C18H12ClF2N5O3S
Molecular Weight	451.8
XLogP	2.5
Topological Polar Surface Area	128
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	6
Heavy Atom Count	30
Formal Charge	0
Complexity	750

SMILES

COC1=C(C=C(C=N1)Cl)S(=O)(=O)NC2=C(C(=C(C=C2)F)C#CC3=CN=C(N=C3)N)F

InChI

InChI=1S/C18H12ClF2N5O3S/c1-29-17-15(6-11(19)9-23-17)30(27,28)26-14-5-4-13(20)12(16(14)21)3-2-10-7-24-18(22)25-8-10/h4-9,26H,1H3,(H2,22,24,25)

InChIKey

JGHVXJKGYJYWOP-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2183470-12-2

CID: 134814489

Formula: C18H12ClF2N5O3S

MW: 451.8

Interactive 3D Structure

Loading 3D structure...

Computed Properties

Property	Value
Molecular Weight	451.8
XLogP3	2.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	6
Exact Mass	451.0317445
Monoisotopic Mass	451.0317445
Topological Polar Surface Area	128 Å²
Heavy Atom Count	30
Formal Charge	0
Complexity	750
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Catalog	Name
E2987-5mg	GCN2-IN-1
E2987-01	GCN2-IN-1
E2987-1g	GCN2-IN-1
E2987-100mg	GCN2-IN-1
E2987-25mg	GCN2-IN-1
F3725-20uL	GCN2 Antibody [C18L7]
F3725-100uL	GCN2 Antibody [C18L7]
F3725-01	GCN2 Antibody [C18L7]
F3725-100uL*2	GCN2 Antibody [C18L7]
A5404	GCN2 recombinant monoclonal antibody