Products for Research Use Only
RegisterLogin

INCB057643

CAT: 0957-S8714-02Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0957-S8714-02Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
INCB057643 is a BET inhibitor that binds to the acetylated lysine recognition motifs found in the BRD of BET proteins, thereby preventing the interaction between the BET proteins and acetylated lysines on histones.
CAS Number
1820889-23-3
Target
Epigenetic Reader Domain
Activity
Epigenetics
Molecular Formula
C20H21N3O5S
Storage Conditions
3 years -20°C powder

Chemical Information

Incb-057643

INCB-057643 is under investigation in clinical trial NCT02959437 (Azacitidine Combined With Pembrolizumab and Epacadostat in Subjects With Advanced Solid Tumors (ECHO-206)).

CAS Number1820889-23-3
PubChem CID118467751
IUPAC Name2,2,4-trimethyl-8-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-methylsulfonyl-1,4-benzoxazin-3-one
Molecular FormulaC20H21N3O5S
Molecular Weight415.5
XLogP0.8
Topological Polar Surface Area108
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count29
Formal Charge0
Complexity862
SMILES
CC1(C(=O)N(C2=CC(=CC(=C2O1)C3=CN(C(=O)C4=C3C=CN4)C)S(=O)(=O)C)C)C
InChI
InChI=1S/C20H21N3O5S/c1-20(2)19(25)23(4)15-9-11(29(5,26)27)8-13(17(15)28-20)14-10-22(3)18(24)16-12(14)6-7-21-16/h6-10,21H,1-5H3
InChIKey
VZSAMEOETVNDQH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Incb-057643
CAS: 1820889-23-3
CID: 118467751
Formula: C20H21N3O5S
MW: 415.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight415.5
XLogP30.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass415.12019195
Monoisotopic Mass415.12019195
Topological Polar Surface Area108 Ų
Heavy Atom Count29
Formal Charge0
Complexity862
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C13610-5mgINCB057643

Popular Products