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DCA (Sodium dichloroacetate)

CAT: 0957-S8615-01Size: 100 mgDry Ice: YesHazardous: No
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CAT#:0957-S8615-01Size:100 mg
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Description
DCA (Sodium dichloroacetate), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 μM for PDK2 and PDK4 respectively, has been shown to derepress Na+-K+-2Cl- cotransporter and a mitochondrial potassium-ion channel axis. Sodium dichloroacetate increases reactive oxygen species (ROS) generation, triggers apoptosis in cancer cells, and inhibits tumor growth.
CAS Number
2156-56-1
Synonyms
Dichloroacetic acid, bichloroacetic acid, BCA
Target
Dehydrogenase
Activity
Metabolism
Molecular Formula
C2HCl2O2.Na
Storage Conditions
2 years -80 in solvent

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