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Derazantinib

CAT: 0957-S8609-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-S8609-02Size:5 mg
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Description
Derazantinib is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with IC50 values of 1.8 nM for FGFR2, and 4.5 nM for FGFR1 and 3, showing lower potency for FGFR4 (IC50=34 nM) . It also inhibits RET, DDR2, PDGFRβ, VEGFR and KIT.
CAS Number
1234356-69-4
Synonyms
ARQ-087
Target
FGFR
Activity
Protein Tyrosine Kinase
Molecular Formula
C29H29FN4O
Storage Conditions
3 years -20°C powder

Chemical Information

Derazantinib

Derazantinib is under investigation in clinical trial NCT03230318 (Derazantinib in Subjects With FGFR2 Gene Fusion Positive Inoperable or Advanced Intrahepatic Cholangiocarcinoma).

CAS Number1234356-69-4
PubChem CID46834118
IUPAC Name(6R)-6-(2-fluorophenyl)-N-[3-[2-(2-methoxyethylamino)ethyl]phenyl]-5,6-dihydrobenzo[h]quinazolin-2-amine
Molecular FormulaC29H29FN4O
Molecular Weight468.6
XLogP5.3
Topological Polar Surface Area59.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Heavy Atom Count35
Formal Charge0
Complexity638
SMILES
COCCNCCC1=CC(=CC=C1)NC2=NC=C3C[C@H](C4=CC=CC=C4C3=N2)C5=CC=CC=C5F
InChI
InChI=1S/C29H29FN4O/c1-35-16-15-31-14-13-20-7-6-8-22(17-20)33-29-32-19-21-18-26(24-10-4-5-12-27(24)30)23-9-2-3-11-25(23)28(21)34-29/h2-12,17,19,26,31H,13-16,18H2,1H3,(H,32,33,34)/t26-/m1/s1
InChIKey
KPJDVVCDVBFRMU-AREMUKBSSA-N
Chemical Structure
2D Structure
2D structure of Derazantinib
CAS: 1234356-69-4
CID: 46834118
Formula: C29H29FN4O
MW: 468.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight468.6
XLogP35.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count9
Exact Mass468.23253972
Monoisotopic Mass468.23253972
Topological Polar Surface Area59.1 Ų
Heavy Atom Count35
Formal Charge0
Complexity638
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5764480Derazantinib
B2222-1Derazantinib (ARQ087)
MBS5753001Derazantinib Racemate
T70143-01Derazantinib dihydrochloride
HY-19981BDerazantinib (dihydrochloride)
HY-19981A-01Derazantinib (Racemate)

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