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FM-381

CAT: 0957-S8541-02Size: 5 mgDry Ice: YesHazardous: No
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CAT#:0957-S8541-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FM-381 is a JAK3 specific reversible covalent inhibitor with IC50 of 127 pM for JAK3 and demonstrates 400-, 2,700- and 3,600-fold selectivity over JAK1, JAK2, and TYK2, respectively.
CAS Number
2226521-65-7
Target
JAK
Activity
Angiogenesis
Molecular Formula
C24H24N6O2
Storage Conditions
2 years -80 in solvent

Chemical Information

(E/Z)-2-Cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide
CAS Number2226521-65-7
PubChem CID122197584
IUPAC Name(E)-2-cyano-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-N,N-dimethylprop-2-enamide
Molecular FormulaC24H24N6O2
Molecular Weight428.5
XLogP3.2
Topological Polar Surface Area104
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count32
Formal Charge0
Complexity785
SMILES
CN(C)C(=O)/C(=C/C1=CC=C(O1)C2=NC3=CN=C4C(=C3N2C5CCCCC5)C=CN4)/C#N
InChI
InChI=1S/C24H24N6O2/c1-29(2)24(31)15(13-25)12-17-8-9-20(32-17)23-28-19-14-27-22-18(10-11-26-22)21(19)30(23)16-6-4-3-5-7-16/h8-12,14,16H,3-7H2,1-2H3,(H,26,27)/b15-12+
InChIKey
GJMZWYLOARVASY-NTCAYCPXSA-N
Chemical Structure
2D Structure
2D structure of (E/Z)-2-Cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide
CAS: 2226521-65-7
CID: 122197584
Formula: C24H24N6O2
MW: 428.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight428.5
XLogP33.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass428.19607403
Monoisotopic Mass428.19607403
Topological Polar Surface Area104 Ų
Heavy Atom Count32
Formal Charge0
Complexity785
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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407443FM-381
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A16805-10FM-381 10mg
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A16805-2FM-381 2mg
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