GSK583

CAT: 0957-S8261-02Size: 5 mgDry Ice: YesHazardous: No

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CAT#:0957-S8261-02Size:5 mg

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Description

GSK583 is a highly potent and selective inhibitor of RIP2 kinase with IC50 of 5 nM. GSK583 also inhibits both TNF-α and IL-6 production with IC50 of ~200 nM in explant cultures.

CAS Number

1346547-00-9

Target

RIP kinase

Activity

Apoptosis

Molecular Formula

C20H19FN4O2S

Storage Conditions

2 years -80 in solvent

Chemical Information

Gsk583

a RIP2 kinase inhibitor; structure in first source

CAS Number	1346547-00-9
PubChem CID	67469084
IUPAC Name	6-tert-butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine
Molecular Formula	C20H19FN4O2S
Molecular Weight	398.5
XLogP	4
Topological Polar Surface Area	96.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Heavy Atom Count	28
Formal Charge	0
Complexity	662

SMILES

CC(C)(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=NNC4=C3C=C(C=C4)F

InChI

InChI=1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25)

InChIKey

XLOGLWKOHPIJLV-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1346547-00-9

CID: 67469084

Formula: C20H19FN4O2S

MW: 398.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	398.5
XLogP3	4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	4
Exact Mass	398.12127520
Monoisotopic Mass	398.12127520
Topological Polar Surface Area	96.1 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	662
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
C18146-25mg	GSK583
A16311-10	GSK583 10mg
A16311-2	GSK583 2mg
HY-100339R	GSK583 (Standard)
A16311-100	GSK583 100mg
A16311-1	GSK583 1mg
A16311-50	GSK583 50mg
A16311-25	GSK583 25mg
A16311-5	GSK583 5mg
A16311-500	GSK583 500mg

GSK583

Chemical Information

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