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CHZ868

CAT: 0957-S7899-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-S7899-02Size:25 mg
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Description
CHZ868 is an inhibitor of type II JAK2 with an IC50 value of 0.17 μM in EPOR JAK2 WT Ba/F3 cells. CHZ868 demonstrates 60- to 70-fold higher inhibition of JAK1-/TYK2-mediated nuclear STAT1 translocation compared to pan-JAK inhibitors.
CAS Number
1895895-38-1
Target
JAK
Activity
Angiogenesis
Molecular Formula
C22H19F2N5O2

Chemical Information

Chz868

CHZ868 is a memger of the class of benzimidazoles that is benzimidazole that is substituted by methyl groups at positions 1 and 4, by a 2,4-difluoroanilino group at position 2, and by a (2-acetamidopyridin-4-yl)oxy group at position 5. It is a type II JAK2 inhibitor with antineoplastic activity. It has a role as an antineoplastic agent and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a member of acetamides, a member of benzimidazoles, a member of pyridines, an aromatic amine, an aromatic ether, a difluorobenzene and a secondary amino compound.

CAS Number1895895-38-1
PubChem CID91885989
IUPAC NameN-[4-[2-(2,4-difluoroanilino)-1,4-dimethylbenzimidazol-5-yl]oxy-2-pyridinyl]acetamide
Molecular FormulaC22H19F2N5O2
Molecular Weight423.4
XLogP3.8
Topological Polar Surface Area81.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity629
SMILES
CC1=C(C=CC2=C1N=C(N2C)NC3=C(C=C(C=C3)F)F)OC4=CC(=NC=C4)NC(=O)C
InChI
InChI=1S/C22H19F2N5O2/c1-12-19(31-15-8-9-25-20(11-15)26-13(2)30)7-6-18-21(12)28-22(29(18)3)27-17-5-4-14(23)10-16(17)24/h4-11H,1-3H3,(H,27,28)(H,25,26,30)
InChIKey
KQQLBXFPTDVFAJ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Chz868
CAS: 1895895-38-1
CID: 91885989
Formula: C22H19F2N5O2
MW: 423.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight423.4
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass423.15068119
Monoisotopic Mass423.15068119
Topological Polar Surface Area81.1 Ų
Heavy Atom Count31
Formal Charge0
Complexity629
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
VAD89538-01CHZ868
A15937-50CHZ868 50mg
A15937-100CHZ868 100mg
A15937-25CHZ868 25mg
A15937-10CHZ868 10mg
A15937-5CHZ868 5mg
A15937-2CHZ868 2mg

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