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Zotiraciclib

CAT: 0957-S7002-02Size: 25 mgDry Ice: YesHazardous: No
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CAT#:0957-S7002-02Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Zotiraciclib (SB1317; TG02) is a novel small molecule potent CDK/JAK2/FLT3 inhibitor, emerged with potent CDK (IC50 against CDKs 1, 2 and 9 = 9, 5 and 3 nM, respectively), FLT3 (IC50 = 19 nM) and JAK2 (IC50 = 19 nM) potency.
CAS Number
937270-47-8
Synonyms
SB1317 (TG02)
Target
JAK
Activity
Angiogenesis
Molecular Formula
C23H24N4O
Storage Conditions
3 years-20°C powder 2 years-80°C in solvent

Chemical Information

6-Methyl-12-oxa-3,6-diaza-2(4,2)-pyrimidina-1,4(1,3)-dibenzenacyclododecaphan-8-ene
CAS Number937270-47-8
PubChem CID67354554
IUPAC Name14-methyl-20-oxa-5,7,14,27-tetrazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2(27),3,5,8,10,12(26),16,21,23-decaene
Molecular FormulaC23H24N4O
Molecular Weight372.5
XLogP4.2
Topological Polar Surface Area50.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count0
Heavy Atom Count28
Formal Charge0
Complexity499
SMILES
CN1CC=CCCOC2=CC=CC(=C2)C3=NC(=NC=C3)NC4=CC=CC(=C4)C1
InChI
InChI=1S/C23H24N4O/c1-27-13-3-2-4-14-28-21-10-6-8-19(16-21)22-11-12-24-23(26-22)25-20-9-5-7-18(15-20)17-27/h2-3,5-12,15-16H,4,13-14,17H2,1H3,(H,24,25,26)
InChIKey
VXBAJLGYBMTJCY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-Methyl-12-oxa-3,6-diaza-2(4,2)-pyrimidina-1,4(1,3)-dibenzenacyclododecaphan-8-ene
CAS: 937270-47-8
CID: 67354554
Formula: C23H24N4O
MW: 372.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight372.5
XLogP34.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count0
Exact Mass372.19501140
Monoisotopic Mass372.19501140
Topological Polar Surface Area50.3 Ų
Heavy Atom Count28
Formal Charge0
Complexity499
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count1
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C12373-25mgZotiraciclib
T70897-01Zotiraciclib HCl
A13454-10Zotiraciclib 10mg
GTR19241909-01Zotiraciclib citrate
HY-15163AZotiraciclib (hydrochloride)
A13454-5Zotiraciclib 5mg
GTR19174390-01(E/Z) -Zotiraciclib
205642Zotiraciclib free base
MBS5773095(E/Z)-Zotiraciclib
MBS5806662(E/Z)-Zotiraciclib citrate

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