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SEA0400

CAT: 0957-S6920-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-S6920-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger (NCX) that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50 of 33 nM, 5.0 nM and 8.3 nM, respectively. SEA0400 prevents sodium nitroprusside (SNP) from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species (ROS) in an extracellular Ca (2+) -dependent manner.
CAS Number
223104-29-8
Target
Calcium Channel
Activity
Neuronal Signaling
Molecular Formula
C21H19F2NO3
Storage Conditions
3 years -20°C powder