Products for Research Use Only
RegisterLogin

SEA0400 (Standard)

CAT: 0804-HY-15515R-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-15515R-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SEA0400 (Standard) is the analytical standard of SEA0400. This product is intended for research and analytical applications. SEA0400 is a novel and selective inhibitor of the Na+-Ca2+ exchanger (NCX), inhibiting Na+-dependent Ca2+ uptake in cultured neurons, astrocytes, and microglia with IC50s of from 5 to 33 nM.
CAS Number
223104-29-8
UNSPSC
12352100
Target
Na+/Ca2+ Exchanger; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cardiovascular Disease
Smiles
NC1=CC(OCC)=CC=C1OC2=CC=C(OCC3=CC(F)=CC=C3F)C=C2
Molecular Formula
C21H19F2NO3
Molecular Weight
371.38
References & Citations
[1]Matsuda T, et al. SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models. J Pharmacol Exp Ther. 2001 Jul;298 (1) :249-56.|[2]Nashida T, et al. The specific Na (+) /Ca (2+) exchange inhibitor SEA0400 prevents nitric oxide-induced cytotoxicity in SH-SY5Y cells. Neurochem Int. 2011 Aug;59 (1) :51-8.|[3]Ago Y, et al. SEA0400, a specific Na+/Ca2+ exchange inhibitor, prevents dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease. Neuropharmacology. 2011 Dec;61 (8) :1441-51.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Sea-0400

SEA0400 is an organic molecular entity. It has a role as an inhibitor.

CAS Number223104-29-8
PubChem CID644100
IUPAC Name2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline
Molecular FormulaC21H19F2NO3
Molecular Weight371.4
XLogP4.8
Topological Polar Surface Area53.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count27
Formal Charge0
Complexity434
SMILES
CCOC1=CC(=C(C=C1)OC2=CC=C(C=C2)OCC3=C(C=CC(=C3)F)F)N
InChI
InChI=1S/C21H19F2NO3/c1-2-25-18-8-10-21(20(24)12-18)27-17-6-4-16(5-7-17)26-13-14-11-15(22)3-9-19(14)23/h3-12H,2,13,24H2,1H3
InChIKey
YSUBLPUJDOWYDP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Sea-0400
CAS: 223104-29-8
CID: 644100
Formula: C21H19F2NO3
MW: 371.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight371.4
XLogP34.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass371.13329979
Monoisotopic Mass371.13329979
Topological Polar Surface Area53.7 Ų
Heavy Atom Count27
Formal Charge0
Complexity434
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-15515-01SEA0400
HY-P2274RArgifin (Standard)
HY-N9362REmodinanthrone (Standard)
HY-N7948RIsomaltotetraose (Standard)
HY-N7640RDeoxylimonin (Standard)
HY-N7617RToralactone (Standard)
HY-N7541RAntrodin A (Standard)
HY-N6739RBeauvericin (Standard)
HY-N6687RCalcimycin (Standard)
HY-N3373RLoganetin (Standard)

Alternative Products

CatalogName
A3811-50SEA0400
A15236-5SEA0400 5mg
A15236-100SEA0400 100mg
A15236-50SEA0400 50mg
A15236-25SEA0400 25mg
A15236-1SEA0400 1mg
A15236-500SEA0400 500mg
A15236-10SEA0400 10mg
A15236-2SEA0400 2mg
SF9006-25mgSEA0400 (NCX inhibitor)

Popular Products