Products for Research Use Only
RegisterLogin

MD-224

CAT: 0957-S6900-02Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0957-S6900-02Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MD-224 is a highly potent and effective degrader of the Human murine double minute 2 (MDM2) protein, the main cellular inhibitor of the tumor suppressor p53. It strongly inhibits cell growth in leukemia cell lines with wild-type p53 and induces complete and lasting tumor regression in the RS4;11 xenograft tumor model.
CAS Number
2136247-12-4
Target
MDM2/MDMX
Activity
Apoptosis
Molecular Formula
C48H43Cl2FN6O6

Chemical Information

(3'R,4'S,5'R)-6''-Chloro-4'-(3-chloro-2-fluorophenyl)-N-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-yn-1-yl)carbamoyl)phenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide
CAS Number2136247-12-4
PubChem CID131986956
Molecular FormulaC48H43Cl2FN6O6
Molecular Weight889.8
XLogP5.9
Topological Polar Surface Area166
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Heavy Atom Count63
Formal Charge0
Complexity1880
SMILES
C1CCC2(CC1)[C@@]3([C@H]([C@@H](N2)C(=O)NC4=CC=C(C=C4)C(=O)NCCCC#CC5=C6CN(C(=O)C6=CC=C5)C7CCC(=O)NC7=O)C8=C(C(=CC=C8)Cl)F)C9=C(C=C(C=C9)Cl)NC3=O
InChI
InChI=1S/C48H43Cl2FN6O6/c49-29-16-19-34-36(25-29)54-46(63)48(34)39(32-12-8-13-35(50)40(32)51)41(56-47(48)22-4-2-5-23-47)44(61)53-30-17-14-28(15-18-30)42(59)52-24-6-1-3-9-27-10-7-11-31-33(27)26-57(45(31)62)37-20-21-38(58)55-43(37)60/h7-8,10-19,25,37,39,41,56H,1-2,4-6,20-24,26H2,(H,52,59)(H,53,61)(H,54,63)(H,55,58,60)/t37?,39-,41+,48+/m0/s1
InChIKey
ZLGNYFOIDAVMHY-MPKOGUQCSA-N
Chemical Structure
2D Structure
2D structure of (3'R,4'S,5'R)-6''-Chloro-4'-(3-chloro-2-fluorophenyl)-N-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-yn-1-yl)carbamoyl)phenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide
CAS: 2136247-12-4
CID: 131986956
Formula: C48H43Cl2FN6O6
MW: 889.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight889.8
XLogP35.9
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count8
Rotatable Bond Count9
Exact Mass888.2605167
Monoisotopic Mass888.2605167
Topological Polar Surface Area166 Ų
Heavy Atom Count63
Formal Charge0
Complexity1880
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
E6569-01MD-4251
E7527ATN-224
E7527-5mgATN-224
S7309-50mgBAY 87-2243
S7309-1gBAY 87-2243
S7309-10mM/1mLBAY 87-2243
S7309-10mgBAY 87-2243
S7309-200mgBAY 87-2243
S7309-01BAY 87-2243

Alternative Products

CatalogName
MBS3611907-01MD-224
A18712-10MD-224 10mg
A18712-50MD-224 50mg
A18712-25MD-224 25mg
A18712-1MD-224 1mg
A18712-200MD-224 200mg
A18712-100MD-224 100mg
A18712-5MD-224 5mg
A18712-10mM-DMD-224 10mM * 1mL in DMSO

Popular Products