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Crizotinib hydrochloride

CAT: 0957-S5190-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-S5190-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Crizotinib (PF-02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c-Met and nucleophosmin (NPM) -anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell-based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0.025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines.
CAS Number
1415560-69-8
Synonyms
Xalkori, PF-02341066 hydrochloride
Target
C-Met
Activity
Protein Tyrosine Kinase
Molecular Formula
C21H23Cl3FN5O
Storage Conditions
3 years -20°C powder

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