SMER3

CAT: 0957-S4925-01Size: 10 mgDry Ice: YesHazardous: No

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CAT#:0957-S4925-01Size:10 mg

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Description

SMER3, the small-molecule enhancer of rapamycin (SMER), is an inhibitor of the Skp1-Cullin-F-box (SCF) Met30 ubiquitin ligase with IC50 of 51 nM.

CAS Number

67200-34-4

Target

E3 Ligase

Activity

Ubiquitin

Molecular Formula

C11H4N4O2

Storage Conditions

2 years -80 in solvent

Chemical Information

Smer3

LSM-42773 is an aromatic ketone.

CAS Number	67200-34-4
PubChem CID	568763
IUPAC Name	13-oxa-10,12,14,16-tetrazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-one
Molecular Formula	C11H4N4O2
Molecular Weight	224.17
XLogP	1.2
Topological Polar Surface Area	81.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	0
Heavy Atom Count	17
Formal Charge	0
Complexity	350

SMILES

C1=CC=C2C(=C1)C3=NC4=NON=C4N=C3C2=O

InChI

InChI=1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H

InChIKey

SFSSAKVWCKFRHE-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 67200-34-4

CID: 568763

Formula: C11H4N4O2

MW: 224.17

Interactive 3D Structure

Loading 3D structure...

Computed Properties

Property	Value
Molecular Weight	224.17
XLogP3	1.2
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	0
Exact Mass	224.03342538
Monoisotopic Mass	224.03342538
Topological Polar Surface Area	81.8 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	350
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Catalog	Name
HY-10949-01	SMER3
TBI1356-25MG	SMER3, E3 Ubiquitin ligase inhibitor