Products for Research Use Only
RegisterLogin

SMER3

CAT: 0421-27718-2Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0421-27718-2Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Small Molecule Enhancer of Rapamycin 3 (SMER3) is a specific inhibitor of the ubiquitin E3 ligase SCFMET30. SMER3 binds directly to the F-box subunit Met30 and blocks binding to the SCF core complex. Cell permeable. Significant inhibition is typically seen at 30-100 μM.
CAS Number
67200-34-4
Applications
Useful for the inhibition of SCFMET30 in cell-based orin vitroassays.
Purity
> 98% by TLC.
Format
Yellow powder
Solubility
Soluble in DMSO (up to 20 mg/mL, with heating)
Molecular Formula
C11H4N4O2S
Shipping Conditions
Room Temperature or Gel Packs
Storage Conditions
Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 2 months.
Calculated Molecular Weight
224.2 Da

Chemical Information

Smer3

LSM-42773 is an aromatic ketone.

CAS Number67200-34-4
PubChem CID568763
IUPAC Name13-oxa-10,12,14,16-tetrazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2,4,6,9,11,14-heptaen-8-one
Molecular FormulaC11H4N4O2
Molecular Weight224.17
XLogP1.2
Topological Polar Surface Area81.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count0
Heavy Atom Count17
Formal Charge0
Complexity350
SMILES
C1=CC=C2C(=C1)C3=NC4=NON=C4N=C3C2=O
InChI
InChI=1S/C11H4N4O2/c16-9-6-4-2-1-3-5(6)7-8(9)13-11-10(12-7)14-17-15-11/h1-4H
InChIKey
SFSSAKVWCKFRHE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Smer3
CAS: 67200-34-4
CID: 568763
Formula: C11H4N4O2
MW: 224.17
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight224.17
XLogP31.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count0
Exact Mass224.03342538
Monoisotopic Mass224.03342538
Topological Polar Surface Area81.8 Ų
Heavy Atom Count17
Formal Charge0
Complexity350
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-10949-01SMER3
TBI1356-25MGSMER3, E3 Ubiquitin ligase inhibitor

Popular Products