AZD5438

CAT: 0957-S2621-03Size: 200 mgDry Ice: YesHazardous: No

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CAT#:0957-S2621-03Size:200 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

AZD5438 is a potent inhibitor of CDK1/2/9 with IC50 of 16 nM/6 nM/20 nM in cell-free assays. It is less potent to CDK5/6 and also inhibits GSK3β.

CAS Number

602306-29-6

Target

CDK

Activity

Cell Cycle

Molecular Formula

C18H21N5O2S

Storage Conditions

2 years -80 in solvent

Chemical Information

4-(2-Methyl-1-(1-methylethyl)-1H-imidazol-5-yl)-N-(4-(methylsulfonyl)phenyl)-2-pyrimidinamine

4-(2-methyl-3-propan-2-yl-4-imidazolyl)-N-(4-methylsulfonylphenyl)-2-pyrimidinamine is a sulfonamide.

CAS Number	602306-29-6
PubChem CID	16747683
IUPAC Name	4-(2-methyl-3-propan-2-ylimidazol-4-yl)-N-(4-methylsulfonylphenyl)pyrimidin-2-amine
Molecular Formula	C18H21N5O2S
Molecular Weight	371.5
XLogP	2.2
Topological Polar Surface Area	98.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Heavy Atom Count	26
Formal Charge	0
Complexity	556

SMILES

CC1=NC=C(N1C(C)C)C2=NC(=NC=C2)NC3=CC=C(C=C3)S(=O)(=O)C

InChI

InChI=1S/C18H21N5O2S/c1-12(2)23-13(3)20-11-17(23)16-9-10-19-18(22-16)21-14-5-7-15(8-6-14)26(4,24)25/h5-12H,1-4H3,(H,19,21,22)

InChIKey

WJRRGYBTGDJBFX-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 602306-29-6

CID: 16747683

Formula: C18H21N5O2S

MW: 371.5

Interactive 3D Structure

Loading 3D structure...

Computed Properties

Property	Value
Molecular Weight	371.5
XLogP3	2.2
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	371.14159610
Monoisotopic Mass	371.14159610
Topological Polar Surface Area	98.2 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	556
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes