MG132

CAT: 0957-S2619-01Size: 5 mgDry Ice: YesHazardous: No

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CAT#:0957-S2619-01Size:5 mg

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Description

MG132 ((S, R, S) - (-) -MG132, Z-Leu-D-Leu-Leu-al) is a potent proteasome (ChTL, TL, and PGPH) inhibitor. MG132 also inhibits calpain (IC50=1.2 μM) . MG132 can be used to induce animal models of Parkinson’s disease.

CAS Number

1211877-36-9

Synonyms

(S, R, S) - (-) -MG-132, Z-Leu-D-Leu-Leu-al

Target

Proteasome

Activity

Proteases

Molecular Formula

C26H41N3O5

Storage Conditions

2 years -80 in solvent

Chemical Information

Benzyl n-[(2s)-4-methyl-1-[[(2r)-4-methyl-1-[[(2s)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate

D-leucinamide, n-[(phenylmethoxy)carbonyl]-l-leucyl-n-[(1s)-1-formyl-3-methylbutyl]- is a peptide.

CAS Number	1211877-36-9
PubChem CID	45103781
IUPAC Name	benzyl N-[(2S)-4-methyl-1-[[(2R)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
Molecular Formula	C26H41N3O5
Molecular Weight	475.6
XLogP	4.8
Topological Polar Surface Area	114
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	15
Heavy Atom Count	34
Formal Charge	0
Complexity	644

SMILES

CC(C)C[C@@H](C=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1

InChI

InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22+,23-/m0/s1

InChIKey

TZYWCYJVHRLUCT-ZRBLBEILSA-N

Chemical Structure

2D Structure

CAS: 1211877-36-9

CID: 45103781

Formula: C26H41N3O5

MW: 475.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	475.6
XLogP3	4.8
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	15
Exact Mass	475.30462142
Monoisotopic Mass	475.30462142
Topological Polar Surface Area	114 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	644
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
C08724-100mg	MG132
574782	(R)-MG132
C02249-25mg	MG132 SSS
27230	(S)-MG132
MBS1128824-01	Recombinant Mycoplasma genitalium Uncharacterized HIT-like protein MG132 (MG132)
226814-01	Z-Leu-Leu-Leu-CHO (Z-LLL-CHO, Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, MG132) discontinued. See 283011

MG132

Chemical Information

Alternative Products

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