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Berberine chloride

CAT: 0957-S2271-01Size: 10 mgDry Ice: YesHazardous: No
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CAT#:0957-S2271-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Berberine chloride is a quaternary ammonium salt from the group of isoquinoline alkaloids. Berberine activates caspase 3 and caspase 8, cleavage of poly ADP-ribose polymerase (PARP) and the release of cytochrome c. Berberine chloride decreases the expression of c-IAP1, Bcl-2 and Bcl-XL. Berberine chloride induces apoptosis with sustained phosphorylation of JNK and p38 MAPK, as well as generation of the ROS. Berberine chloride is a dual topoisomerase I and II inhibitor. Berberine chloride is also a potential autophagy modulator.
CAS Number
633-65-8
Synonyms
NSC 646666, Natural Yellow 18 chloride
Target
Anti-infection
Activity
Microbiology
Molecular Formula
C20H18NO4.Cl
Storage Conditions
2 years -80 in solvent

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