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ATX968

CAT: 0957-E5836-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-E5836-02Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ATX968 (DHX9-IN-2) is a potent, selective, and orally bioavailable inhibitor of DHX9 helicase with an IC50 of 8 nM. It induces strong and sustained tumor growth inhibition or regression in MSI-H/dMMR colorectal cancer (CRC) xenograft models.
CAS Number
2973395-71-8
Synonyms
DHX9-IN-2
Target
DNA/RNA Synthesis
Activity
Cell Cycle
Molecular Formula
C18H16ClN3O3S2

Chemical Information

Dhx9-IN-2
CAS Number2973395-71-8
PubChem CID169144997
IUPAC NameN-[3-chloro-5-(methanesulfonamido)phenyl]-4-(3-methyl-2-pyridinyl)thiophene-2-carboxamide
Molecular FormulaC18H16ClN3O3S2
Molecular Weight421.9
XLogP3.3
Topological Polar Surface Area125
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count27
Formal Charge0
Complexity628
SMILES
CC1=C(N=CC=C1)C2=CSC(=C2)C(=O)NC3=CC(=CC(=C3)Cl)NS(=O)(=O)C
InChI
InChI=1S/C18H16ClN3O3S2/c1-11-4-3-5-20-17(11)12-6-16(26-10-12)18(23)21-14-7-13(19)8-15(9-14)22-27(2,24)25/h3-10,22H,1-2H3,(H,21,23)
InChIKey
VDGNPEFFHQRGOP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dhx9-IN-2
CAS: 2973395-71-8
CID: 169144997
Formula: C18H16ClN3O3S2
MW: 421.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight421.9
XLogP33.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass421.0321614
Monoisotopic Mass421.0321614
Topological Polar Surface Area125 Ų
Heavy Atom Count27
Formal Charge0
Complexity628
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C03597-01ATX968
A24287-50ATX968 (DHX9-IN-2) 50mg
A24287-5ATX968 (DHX9-IN-2) 5mg
A24287-100ATX968 (DHX9-IN-2) 100mg
A24287-10ATX968 (DHX9-IN-2) 10mg

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