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NLRP3/AIM2-IN-3

CAT: 0957-E5801-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-E5801-01Size:5 mg
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Description
NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with species-specific effects on NLRP3 and AIM2 inflammasome-mediated pyroptosis. It demonstrates potent inhibition of pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 μM. It also disrupts the interaction between NLRP3 or AIM2 and the adaptor protein ASC, effectively preventing ASC oligomerization and blocking inflammasome assembly.
CAS Number
1787787-60-3
Target
NLRP3
Activity
Immunology & Inflammation
Molecular Formula
C16H14N2O2

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